Good day to you and thanks for your enquiry! It’s a bit hard for me to say what is the best serum for YOU to use as I do not know what your skin looks like. But if you had to ask me which serum I believe is the best product which really takes care of everything, I would say Skin Medica’s Essential Serum. It containds Growth Factors, Anti Oxidants, Peptides and a whole lot of speciality ingredients that pretty much cover everything an ageing skin needs.