Thank-you so much for your enquiry. You can most definately start using more active ingredients. The mature skin certainly needs more help and more activity to keep that skin alive and working as we age. I’m not sure that just using Nimue on its own is necesarily the best option for you. I always cherry pick the best products from various ranges to make up the best overall skin care plan for my patients. So by all means, I am a big fan of Nimue, choose your cleanser, conditioner, and exfoliation products from the Nimue range, but i think when it comes to your serums you need to incorporate growth factors at your age (which Nimue doesn’t have in their range), so simply incorporate a growth factor serum like Lamelle’s serum from the Dermaheal Range. I would also encourage you to use a product or serum that contains a high amount of Vitamin A at night time. Of course sun protection is absolutely vital every single day and Nimue’s sunblock is fantastic.